Propionic Acid (E280) β€” What You Need to Know

Generally Safe(7/10)Natural
7
GENERALLY SAFE
Safety Score: 7/10

What Is Propionic Acid?

Propionic acid is an organic acid that occurs naturally in Swiss cheese, produced by Propionibacterium during fermentation. It is widely used as a mold inhibitor in bread and baked goods. While it can be produced naturally, the commercial form used as a food additive is typically synthesized industrially.

What Is It Used For?

Used primarily as a mold inhibitor in bread and baked goods, extending shelf life by preventing fungal growth. Also used in cheese production and animal feed preservation.

Function: Preservative, mold inhibitor, antimicrobial agent
5 mg
Typical daily intake

Safety Assessment

πŸ“Š
Acceptable Daily Intake (ADI)
Not specified mg/kg bw/day
πŸ›οΈ
Regulatory Status
πŸ‡ΊπŸ‡Έ USA (FDA): GRAS (Generally Recognized as Safe).
πŸ‡ͺπŸ‡Ί EU (EFSA): No numerical ADI established. Considered safe at current food-use levels but under ongoing review following metabolic studies.
⚠️ Key Concerns

Naturally produced by Propionibacterium in Swiss cheese production. Effective mold inhibitor widely used in bread. Some studies (2019, Science Translational Medicine) suggested propionic acid may impair insulin signaling and increase glucagon production. EFSA noted these findings but has not changed its assessment. The amounts used in food are much lower than those in animal studies. Generally considered safe at food-use levels. A 2019 Harvard study raised questions about metabolic effects at high doses.

Our Assessment

Based on current evidence, Propionic Acid is rated Generally Safe with a score of 7/10. This is 1.3 points above the average for preservatives (5.7/10). Last reviewed by regulators: 2014.

Commonly Found In

BreadBaked goodsCheeseAnimal feedFlour tortillas
Example brands:
WarburtonsHovisBimbo

Always check the label for E280 or 'Propionic Acid'

β–ΆChemical Information
Formula: C3H6O2
Molecular Weight: 74.08 g/mol
CAS Number: 79-09-4
INS Number: 280
Also known as: E280, INS 280, Propanoic acid, Ethylformic acid

Frequently Asked Questions about Propionic Acid

Propionic Acid has a Safety Score of 7/10 (Generally Safe). Naturally produced by Propionibacterium in Swiss cheese production. Effective mold inhibitor widely used in bread. Some studies (2019, Science Translational Medicine) suggested propionic acid may impair insulin signaling and increase glucagon production. EFSA noted these findings but has not changed its assessment. The amounts used in food are much lower than those in animal studies. Generally considered safe at food-use levels. A 2019 Harvard study raised questions about metabolic effects at high doses.

Quick Facts

E-Number
E280
INS Number
280
Origin
Natural
FDA Status
GRAS (Generally Recognized as Safe).
EFSA Status
No numerical ADI established. Considered safe at current food-use levels but under ongoing review following metabolic studies.
ADI
Not specified mg/kg bw/day
Last Review
2014
Dietary Compatibility
Vegan: βœ… YesHalal: βœ… YesKosher: βœ… YesGluten-Free: βœ… Yes
Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional for health-related decisions.

Related Additives

Other preservatives in the same family