Natamycin (E235) — What You Need to Know

Generally Safe(7/10)Natural
7
GENERALLY SAFE
Safety Score: 7/10

What Is Natamycin?

Natamycin, also known as pimaricin, is a natural antifungal compound produced by the soil bacterium Streptomyces natalensis through fermentation. It is a polyene macrolide antibiotic used at very low concentrations as a surface treatment to prevent mould growth on cheese and cured meats. It is not absorbed through the intact gastrointestinal tract.

What Is It Used For?

Applied as a surface treatment on cheese rinds and sausage casings to prevent mould and yeast growth. Used at very low concentrations to extend the shelf life of dairy and cured meat products without affecting flavour or appearance.

Function: Preservative, antifungal agent
0.1 mg
Typical daily intake
21 mg
Max safe daily (70 kg adult)
0.5%
of ADI (typical diet)

Safety Assessment

📊
Acceptable Daily Intake (ADI)
0.3 mg/kg bw/day
🏛️
Regulatory Status
🇺🇸 USA (FDA): GRAS (approved for cheese surface treatment)
🇪🇺 EU (EFSA): Authorized — evaluated in 2009, confirmed safe at approved levels
⚠️ Key Concerns

Polyene macrolide antifungal antibiotic used at very low concentrations (surface treatment only). WHO raised concern about potential contribution to antimicrobial resistance, but EFSA concluded in 2009 that use at approved levels does not contribute to resistance. Very low ADI (0.3 mg/kg bw/day) reflects caution. Not absorbed through intact GI tract. Limited to surface treatment of cheese and sausages in EU.

Our Assessment

Based on current evidence, Natamycin is rated Generally Safe with a score of 7/10. This is 1.3 points above the average for preservatives (5.7/10). Last reviewed by regulators: 2009. A typical diet provides about 0.5% of the acceptable daily intake.

Commonly Found In

Cheese rindsSausage casingsDried cured meatsYogurtBeverages
Example brands:
BabybelCastelloPrésident

Always check the label for E235 or 'Natamycin'

Chemical Information
Formula: C33H47NO13
Molecular Weight: 665.73 g/mol
CAS Number: 7681-93-8
INS Number: 235
Also known as: E235, INS 235, Pimaricin, Natamycin

Frequently Asked Questions about Natamycin

Natamycin has a Safety Score of 7/10 (Generally Safe). Polyene macrolide antifungal antibiotic used at very low concentrations (surface treatment only). WHO raised concern about potential contribution to antimicrobial resistance, but EFSA concluded in 2009 that use at approved levels does not contribute to resistance. Very low ADI (0.3 mg/kg bw/day) reflects caution. Not absorbed through intact GI tract. Limited to surface treatment of cheese and sausages in EU.

Quick Facts

E-Number
E235
INS Number
235
Origin
Natural
FDA Status
GRAS (approved for cheese surface treatment)
EFSA Status
Authorized — evaluated in 2009, confirmed safe at approved levels
ADI
0.3 mg/kg bw/day
Last Review
2009
Dietary Compatibility
Vegan: ✅ YesHalal: ✅ YesKosher: ✅ YesGluten-Free: ✅ Yes
Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional for health-related decisions.

Related Additives

Other preservatives in the same family