Calcium Citrate (E333) β€” What You Need to Know

Safe(9/10)Synthetic
9
SAFE
Safety Score: 9/10

What Is Calcium Citrate?

Calcium citrate is the calcium salt of citric acid, a white crystalline powder used extensively as both a food additive and a calcium supplement. It is one of the most bioavailable forms of supplemental calcium, particularly effective when taken without food. It serves as an acidity regulator and firming agent in processed foods.

What Is It Used For?

Used as a calcium fortifier in juices and foods, as an acidity regulator in processed products, and as a preferred calcium supplement form for individuals with low stomach acid.

Function: Acidity regulator, firming agent, calcium supplement

Safety Assessment

πŸ“Š
Acceptable Daily Intake (ADI)
Not specified mg/kg bw/day
πŸ›οΈ
Regulatory Status
πŸ‡ΊπŸ‡Έ USA (FDA): GRAS (Generally Recognized as Safe)
πŸ‡ͺπŸ‡Ί EU (EFSA): ADI not specified β€” considered safe with no numerical limit needed
⚠️ Key Concerns

Calcium salt of citric acid, widely used as a calcium supplement. Better absorbed than calcium carbonate when taken on an empty stomach (does not require stomach acid for absorption). Also used as an acidity regulator and firming agent. No safety concerns. Provides approximately 21% elemental calcium. Preferred calcium source for people taking proton pump inhibitors (PPIs) or with low stomach acid.

Our Assessment

Based on current evidence, Calcium Citrate is rated Safe with a score of 9/10. This is 0.2 points above the average for acidity regulators (8.8/10). Last reviewed by regulators: 2017.

Commonly Found In

Calcium-fortified juicesTofuDietary supplementsInfant formulaCanned vegetables
Example brands:
Tropicana (calcium-fortified OJ)Citracal (supplements)

Always check the label for E333 or 'Calcium Citrate'

β–ΆChemical Information
Formula: Ca3(C6H5O7)2
Molecular Weight: 498.43 g/mol
CAS Number: 813-94-5
INS Number: INS 333
Also known as: E333, INS 333, Tricalcium dicitrate, Tricalcium citrate

Frequently Asked Questions about Calcium Citrate

Calcium Citrate has a Safety Score of 9/10 (Safe). Calcium salt of citric acid, widely used as a calcium supplement. Better absorbed than calcium carbonate when taken on an empty stomach (does not require stomach acid for absorption). Also used as an acidity regulator and firming agent. No safety concerns. Provides approximately 21% elemental calcium. Preferred calcium source for people taking proton pump inhibitors (PPIs) or with low stomach acid.

Quick Facts

E-Number
E333
INS Number
INS 333
Origin
Synthetic
FDA Status
GRAS (Generally Recognized as Safe)
EFSA Status
ADI not specified β€” considered safe with no numerical limit needed
ADI
Not specified mg/kg bw/day
Last Review
2017
Dietary Compatibility
Vegan: βœ… YesHalal: βœ… YesKosher: βœ… YesGluten-Free: βœ… Yes
Disclaimer: This information is for educational purposes only and is not medical advice. Always consult a healthcare professional for health-related decisions.

Related Additives

Other acidity regulators in the same family